张季平

姓名：张季平

职称：教授

联系电话：021-62232017

电子邮箱：jpzhang@bio.ecnu.edu.cn

通讯地址：上海市中山北路3663号华东师范大学理科大楼B305

研究方向： 听觉神经生物学

个人简介：

听觉信息处理及功能可塑性研究室PI

张季平于1988、1991和1999年分别获得华东师范大学生物学专业学士学位、生理学硕士学位、生理学博士学位。1991.7-1996.8在湖北大学生命科学系工作；1997.12-1999.7在美国密苏里大学做访问学者；1999.7-2000.10在华东师范大学做博士后; 2000.11-2004.12年在美国加州大学Irvine分校解剖与神经生物学系做博士后。2005年至今被聘为华东师范大学教授。

主要研究内容：1)环境和经验依赖的听觉功能发育及可塑性; 2)复杂声学环境下脑对听觉信息的处理机制; 3)听觉学习与记忆。

研究内容简介：

听觉系统的功能在出生后有一个逐步发育和完善的过程，并易受到声环境和感觉经验的影响。我们用行为学、电生理学和分子生物学的方法研究出生后环境和经验依赖的听觉功能的发育与可塑性机理，为研究听觉功能障碍的修复策略提供实验和理论基础。

人和动物在复杂的声环境中能较好地感知和分辨目标声信息，但相关的脑机制并未揭示清楚。我们用电生理学方法研究在复杂声学环境下脑对听觉信息（频率、强度、时间、声源方位）的处理机制，希望阐明在复杂声学环境下听觉系统抗噪声干扰的神经机制，为听觉信息处理相关的仿生学和人工智能提供理论模型。此外，我们尚在探索动物社会学习行为的表现和相关机制。

主持的科研项目：

1. 听皮层和下丘对双耳听觉信息整合的发育及可塑性 （国家自然科学基金，NSFC 31671082, 2017-2020）

2.在复杂声学环境下听皮层和下丘对目标声频率信息的编码 (国家自然科学基金，NSFC 31371117, 2014-2017)

3.生物脑听觉信息处理的神经机制、建模及算法 (973项目子课题，2015-2017)

4.大脑听皮层对声刺激时间信息编码的发育及可塑性 (国家自然科学基金，NSFC 31171058, 2012-2015)。

5.复杂声环境下大脑听皮层神经元对声音空间信息的动态编码(国家自然科学基金，NSFC 30970984, 2010-2012)。

实验手段：

• 神经电生理学

• 动物行为学

• 分子生物学

发表论文：

1. Wang X., Liu J., Zhang J.*, Chronic unilateral hearing loss disrupts neural tuning to sound-source azimuth in the rat primary auditory cortex, Frontiers in Neuroscience, 2019, 13:477

2. Wang F., Liu J., Zhang J.*, Early postnatal noise exposure degrades the stimulus-specific adaptation of neurons in the rat auditory cortex in adulthood, Neuroscience, 2019, 404:1-13

3. Gao F., Chen L., Zhang J.*, Nonuniform impacts of forward suppression on neural responses to preferred stimuli and nonpreferred stimuli in the rat auditory cortex, European Journal of Neuroscience, 2018, 47(11): 1320-1338.

4. Lu Q., Jiang C., Zhang J.*, Encoding of sound envelope transients in the auditory cortex of juvenile rats and adult rats, International Journal of Developmental Neuroscience, 2016, 48:50-57.

5. Jiang C., Xu X., Yu L., Xu J.*, Zhang J.*, Environmental enrichment rescues the degraded auditory temporal resolution of cortical neurons induced by early noise exposure, European Journal of Neuroscience, 2015, 42 (5):2144-2154.

6. Zhao Y., Xu X., He J., Xu J., Zhang J.*, Age-related changes in neural gap detection thresholds in the rat auditory cortex, European Journal of Neuroscience, 2015, 41(3): 285-292.

7. Peng Y., Xing P., He J., Sun X., Zhang J.*, The impact of preceding noise on the frequency tuning of rat auditory cortex neurons, BMC Neuroscience, 2012, 13:70.

8. Peng Y.‚ Sun X.‚ Zhang J.* ‚ Contextual modulation of frequency tuning of neurons in the rat auditory cortex‚ Neuroscience‚ 2010‚ 169:1403-1413.

9. Cai R.‚ Zhou X.‚ Guo F.‚ Xu J.‚ Zhang J.*‚ Sun X.*‚ Maintenance of enriched environment-induced changes of auditory spatial sensitivity and expression of GABA(A)‚ NMDA‚ and AMPA receptor subunits in rat auditory cortex‚ Neurobiology of Learning and Memory‚ 2010‚ 94(4):452-460.

10. Zhang J.*‚ Nakamoto K.T.‚ Kitzes L.M‚ Responses of Neurons in the Cat Primary Auditory Cortex to Sequential Sounds. Neuroscience‚ 2009‚ 161:578-588.

11. Gao F.‚ Zhang J.*‚ Sun X.‚ Chen L.‚ The effect of postnatal exposure to noise on sound level processing by auditory cortex neurons of rats in adulthood‚ Physiology & Behavior‚ 2009‚ 97:369-373

12. Zhang J.*‚ Chen L.‚ Gao F.‚ Pu Q.‚ Sun‚ X.‚ Noise exposure at young age impairs auditory object exploration behavior of rats in adulthood‚ Physiology & Behavior‚ 2008‚ 95(1-2):229-234.

13. Nakamoto K.T.‚ Zhang J.‚ Kitzes L.M.*‚ Temporal nonlinearity during recovery from sequential inhibition by neurons in the cat primary auditory cortex.  Journal of Neurophysiology, 2006, 95(3):1897-1907.

14. Zhang J.‚ Nakamoto K. T.‚ and Kitzes L.M.*‚ Modulation of level response area and stimulus selectivity of neurons in cat primary auditory cortex‚ Journal of Neurophysiology, 2005, 94(4):2263-2274.

15. Zhang J.‚ Nakamoto K. T.‚ and Kitzes L.M.*‚ Binaural interaction revisited in the cat primary auditory cortex. Journal of Neurophysiology 2004, 91(1): 101-117.

16. Nakamoto K.T.‚ Zhang J.‚ and Kitzes L.M.*‚ Response patterns along an isofrequency contour in cat primary auditory cortex (AI) to stimuli varying in average and interaural levels. Journal of Neurophysiology‚ 2004, 91(1): 118-135.

17. Zhang J.‚ Jen P.H.S.*‚ Sun X.‚ Direction-dependent corticofugal modulation of frequency-tuning curves of inferior collicular neurons in the big brown bat‚ Eptesicus fuscus.  Journal of Comparative Physiology [A]. 2000‚186(10):913-922.

18. Zhang J.P.*‚ Sun X.D.‚ Jen P.H.S.，Corticofugal modulation of frequency tuning of inferior collicular neurons in big brown bat‚ Eptesicus fuscus. CHINESE SCIENCE BULLETIN‚ 2001‚ 46 (10): 836-839.

19. Jen P.H.S.*‚ Zhang J.‚ The role of GABAergic inhibition on direction-dependent sharpening of frequency tuning in bat inferior collicular neurons. Brain Research. 2000‚ 862(1-2):127-137.

20. Jen P.H.-S.*, Zhang J.‚ Corticofugal regulation of excitatory and inhibitory frequency tuning curves of bat inferior collicular neurons.  Brain Research, 1999‚ 841:184-188.

研究团队：

博士生： 刘静，陈冠华，李岩

硕士生： 张赢心，汪晓荷，张嘉倚，袁欣然，段伊萱，唐哲一